|
KMID : 0378019710140050054
|
|
New Medical Journal
1971 Volume.14 No. 5 p.54 ~ p.58
|
|
|
Effect of ginseng on nucleic acid content of mandibular gland of rats
|
|
|
|
|
Abstract
|
|
|
A study was planned to see if administration of ginseng extract has any influence upon the nucleic acid content of the mandibular gland of rats, and to estimate the effect of ACTH administration upon the nucleic acid content of rats previously primed with ginseng. Ninety male rats (body weight: 150-200 gm) were divided into the ginseng, the saline, and the normal groups, which received for 5 days 0.5 ml /100 gm body weight of ginseng extract solution (4 mg of ginseng alcohol extract in 1 ml of saline), same amount of saline, or no medication, respectively. On the 5th experimental day, each of the 3 groups was further divided into 2 subgroups yielding the ginseng, the ginseng-ACTH, the saline, the saline￢ACTH, the normal, and the normal-ACTH subgroups. The ginseng, the saline, and the normal subgroups were sacrificed 2 hours after the last medication, while the ginseng-ACTH, the saline-ACTH, and the normal-ACTH subgroups received ACTH (0.1 unit/subject) 1 hour after the last medication and were sacrificed after 1 more hour. The mandibular gland was measured for RNA and DNA contents using the chemical method of Schmidt-Thanhauser-Schneider.
Following results were obtained
1. RNA content of the mandibular gland and RNA/DNA ratio were significantly higher in the ginseng group than they were in the normal and the saline groups. The DNA content was significantly reduced in the ginseng group.
2. Administration of ACTH reduced nucleic acid contents of the mandibular gland. In the ginseng group the rate of decrease ((value of ginseng-ACTH subgroup-value of ginseng subgroup) X 100/value of ginseng subgroup) in RNA and RNA/DNA ratio were more conspicuous than they were in the normal and the saline groups. The rate of decrease in DNA after ACI´II was less conspicuous in the ginseng group.
Thus under the influence of ginseng the mandibular glandular RNA content and RNA/DNA ratio increased significantly and DNA content decreased conspicuously while under additional influence of ACTH the rate of decrease was conspicuous in RNA content and RNA/DNA ratio but it was less so in DNA content.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|